Soutenance de thèse de Jianfei SONG

Vous êtes cordialement invité(e)s à la soutenance de thèse de Mme. Jianfei SONG, qui a mené ses travaux de recherche en vue de l'obtention du grade de Docteur des Arts et Métiers, au sein du Laboratoire d'Ingénierie des Fluides et Systèmes Energétiques (Arts et Métiers Institut de Technologie, Cnam, LIFSE, HESAM Université). 

La soutenance aura lieu le lundi 15 février 2021 à 14h. Exceptionnellement, cette soutenance se déroulera à distance, par visioconférence, pour respecter les consignes mises en place par nos tutelles, pour limiter les risques de pandémie de COVID-19. Pour assister à cette soutenance, il suffira de se connecter à l'outil "Teams" en cliquant sur le lien internet suivant: https://bit.ly/3rDELFs

(Contacter l'équipe encadrante pour toute demande)

La thèse de Mme. Jianfei SONG, dirigée par M. Smaïne KOUIDRI, et co-encadrée par M. Farid BAKIR s'intitule : "Numerical study of control parameters on hemodynamic and drug eluting stent coupling".

Le jury sera composé de :

Résumé de la thèse:

Cardiovascular disease has been strongly threatening people's life leading to heart attacks, strokes and even deaths especially in western countries. Confronting the generation of stenosis blocking the blood flow, stent implantation has been a significant progress currently for the treatments. However, the complications following stent implantation require the stent optimization necessarily. In this research work, the computational fluid dynamics has been adopted aiming to better understand the drug release mechanisms from drug-eluting stent (DES) contributing to stent performance. Considering the complexity of biological system, the modeling characteristics of blood flow in coronary artery have been discussed in numerical and mathematical views in the first place. Modeling validation works are followed with the preliminary studies considering arterial geometrical singularities: bifurcation and tortuosity. An insight of hemodynamic variations affected by the artery geometrical singularity has been acquired. Furthermore, with the consideration of stent in artery, the coupling between blood flow and stent performance is achieved. A better understanding of the arterial hemodynamic variations caused by the stent has been provided considering stent design factors. Finally, we step into the coupling between flow mechanisms and mass transfer from DES. The drug transport process from polymer into lumen and tissue domains is investigated separately. Both numerical and experimental works are involved to achieve the experimental validation for drug release from polymer as the experimental validation works are quite missing in the current literature.